Clinical, histological and immunohistochemical features of ectomesenchymal chondromyxoid tumor

Objective Ectomesenchymal chondromyxoid tumor is a rare oral soft tissue neoplasm that should be differentiated from other neural and chondromyxoid entities. The aim of this study was to report the clinical, histological, and immunohistochemical features of 3 additional cases of this condition. Meth...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2009-12, Vol.108 (6), p.914-919
Main Authors: Pires, Fábio Ramôa, PhD, Abrahão, Aline Correa, DDS, MSc, Cabral, Márcia Grillo, DDS, PhD, Azevedo, Rebeca Souza, DDS, PhD, Horta, Martinho Campolina Rebello, DDS, PhD, Martins, Carlos Roberto, DDS, PhD, de Almeida, Oslei Paes, DDS, PhD, Chen, Sow-Yeh, DDS, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antigens, Neoplasm - immunology
Biological and medical sciences
Child
Dentistry
Humans
Immunohistochemistry
Male
Medical sciences
Mesenchymoma - immunology
Mesenchymoma - pathology
Mesoderm - pathology
Myoepithelioma - immunology
Myoepithelioma - pathology
Myxoma - immunology
Myxoma - pathology
Neoplasms, Germ Cell and Embryonal - immunology
Neoplasms, Germ Cell and Embryonal - pathology
Otorhinolaryngology. Stomatology
Surgery
Tongue Neoplasms - immunology
Tongue Neoplasms - pathology
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Summary:Objective Ectomesenchymal chondromyxoid tumor is a rare oral soft tissue neoplasm that should be differentiated from other neural and chondromyxoid entities. The aim of this study was to report the clinical, histological, and immunohistochemical features of 3 additional cases of this condition. Methods Clinical data were obtained from the clinical records and all cases were evaluated through light microscopy and immunohistochemistry to cytokeratins, vimentin, S100 protein, desmin, smooth muscle actin, and glial fibrilary acidic protein. Results All 3 cases affected the tongue as a long-lasting submucosal swelling and were managed through conservative surgery. They all showed myxoid and chondroid histological patterns, and vimentin, S100, and glial fibrilary acidic protein immunoexpression. Conclusions These findings reinforce the typical features of ectomesenchymal chondromyxoid tumor previously described, helping to confirm and establish the clinical, histopathological, and immunohistochemical profile of this uncommon lesion.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2009.07.007