Clinical, histological and immunohistochemical features of ectomesenchymal chondromyxoid tumor

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2009-12, Vol.108 (6), p.914-919
• Main Authors: Pires, Fábio Ramôa, PhD, Abrahão, Aline Correa, DDS, MSc, Cabral, Márcia Grillo, DDS, PhD, Azevedo, Rebeca Souza, DDS, PhD, Horta, Martinho Campolina Rebello, DDS, PhD, Martins, Carlos Roberto, DDS, PhD, de Almeida, Oslei Paes, DDS, PhD, Chen, Sow-Yeh, DDS, PhD
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Antigens, Neoplasm - immunology; Biological and medical sciences; Child; Dentistry; Humans; Immunohistochemistry; Male; Medical sciences; Mesenchymoma - immunology; Mesenchymoma - pathology; Mesoderm - pathology; Myoepithelioma - immunology; Myoepithelioma - pathology; Myxoma - immunology; Myxoma - pathology; Neoplasms, Germ Cell and Embryonal - immunology; Neoplasms, Germ Cell and Embryonal - pathology; Otorhinolaryngology. Stomatology; Surgery; Tongue Neoplasms - immunology; Tongue Neoplasms - pathology
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1016/j.tripleo.2009.07.007

Objective Ectomesenchymal chondromyxoid tumor is a rare oral soft tissue neoplasm that should be differentiated from other neural and chondromyxoid entities. The aim of this study was to report the clinical, histological, and immunohistochemical features of 3 additional cases of this condition. Methods Clinical data were obtained from the clinical records and all cases were evaluated through light microscopy and immunohistochemistry to cytokeratins, vimentin, S100 protein, desmin, smooth muscle actin, and glial fibrilary acidic protein. Results All 3 cases affected the tongue as a long-lasting submucosal swelling and were managed through conservative surgery. They all showed myxoid and chondroid histological patterns, and vimentin, S100, and glial fibrilary acidic protein immunoexpression. Conclusions These findings reinforce the typical features of ectomesenchymal chondromyxoid tumor previously described, helping to confirm and establish the clinical, histopathological, and immunohistochemical profile of this uncommon lesion.