Functional association of immediate early gene c-fos with nuclear matrix

Accumulation of c-fos gene locus DNA in the nuclear matrix of hepatocyte nuclei was observed during induction of c-fos with cycloheximide. No enhanced association with the nuclear matrix was detected for inactive immunoglobulin gene locus. The use of endogenous DNAses allows isolation of nuclear mat...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-02, Vol.135 (2), p.167-170
Main Authors: Borisova, N P, Kostyuk, G V, Shevchenko, N A, Boikov, P Ya, Rudakova, E V, Papina, R I, Terent'ev, A A
Format: Article
Language:English
Subjects:
Animals
Chromatin - genetics
Chromatin - metabolism
Cycloheximide - metabolism
Gene Expression Regulation
Genes, fos
Hepatocytes - cytology
Hepatocytes - physiology
Immunoglobulin G - genetics
Male
Nuclear Matrix - metabolism
Protein Synthesis Inhibitors - metabolism
Rats
Rats, Wistar
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Summary:Accumulation of c-fos gene locus DNA in the nuclear matrix of hepatocyte nuclei was observed during induction of c-fos with cycloheximide. No enhanced association with the nuclear matrix was detected for inactive immunoglobulin gene locus. The use of endogenous DNAses allows isolation of nuclear matrix preparations enriched with transcribing chromatin.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1023828116743