Propranolol reduces variceal pressure and wall tension in schistosomiasis presinusoidal portal hypertension

Background and Aim:  Although prophylaxis with β‐blockers has been shown to decrease variceal pressure and wall tension in cirrhotic patients, this has not been demonstrated in non‐cirrhotic portal hypertension caused by Schistosoma mansoni infection. Methods:  Thirteen patients without history of p...

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Published in:Journal of gastroenterology and hepatology 2009-12, Vol.24 (12), p.1852-1856
Main Authors: Farias, Alberto Queiroz, Kassab, Fabio, Da Rocha, Evandra Cristina Vieira, Dos Santos Bomfim, Valdinélia, Vezozzo, Denise Cerqueira Paranaguá, Bittencourt, Paulo Lisboa, Carrilho, Flair José
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Adult
Animals
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Diseases caused by trematodes
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Endosonography
Esophageal and Gastric Varices - drug therapy
Esophageal and Gastric Varices - parasitology
Esophageal and Gastric Varices - physiopathology
Esophagoscopy
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Hemorrhage - parasitology
Gastrointestinal Hemorrhage - physiopathology
Gastrointestinal Hemorrhage - prevention & control
Helminthic diseases
Humans
Hypertension, Portal - drug therapy
Hypertension, Portal - parasitology
Hypertension, Portal - physiopathology
Infectious diseases
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Parasitic diseases
Pilot Projects
portal hypertension
propranolol
Propranolol - therapeutic use
Schistosomiases
schistosomiasis
Schistosomiasis mansoni - complications
Schistosomiasis mansoni - drug therapy
Schistosomiasis mansoni - physiopathology
Treatment Outcome
Venous Pressure - drug effects
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Summary:Background and Aim:  Although prophylaxis with β‐blockers has been shown to decrease variceal pressure and wall tension in cirrhotic patients, this has not been demonstrated in non‐cirrhotic portal hypertension caused by Schistosoma mansoni infection. Methods:  Thirteen patients without history of previous gastrointestinal bleeding were included. All of them had high‐risk esophageal varices at endoscopy. An endoscopic gauge and a high‐frequency endoscopic ultrasonography miniprobe were used to assess transmural variceal pressure and wall tension before and after achieving β‐blockade with propranolol. Results:  Baseline variceal pressure decreased from 13.3 ± 3.5 to 8.2 ± 2.0 mmHg (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2009.05912.x