Lower Dose Prednisone Prevents Radioiodine-Associated Exacerbation of Initially Mild or Absent Graves’ Orbitopathy: A Retrospective Cohort Study

Context: Radioiodine (RAI) therapy may cause progression of mild or absent Graves’ orbitopathy (GO), preventable by oral prednisone. Optimal doses of prednisone are undefined. Objective: The aim of this study was to compare the effectiveness of reported doses [starting dose, >0.3 mg/kg body weigh...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2010-03, Vol.95 (3), p.1333-1337
Main Authors: Lai, Adriana, Sassi, Lorenza, Compri, Emanuele, Marino, Franca, Sivelli, Paolo, Piantanida, Eliana, Tanda, Maria Laura, Bartalena, Luigi
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Chi-Square Distribution
Endocrinopathies
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Glucocorticoids - administration & dosage
Graves Disease - pathology
Graves Disease - radiotherapy
Graves Ophthalmopathy - drug therapy
Graves Ophthalmopathy - pathology
Graves Ophthalmopathy - prevention & control
Humans
Iodine Radioisotopes - adverse effects
Male
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Prednisone - administration & dosage
Prednisone - adverse effects
Retrospective Studies
Severity of Illness Index
Sleep Initiation and Maintenance Disorders - chemically induced
Statistics, Nonparametric
Thyroid Gland - drug effects
Thyroid Gland - pathology
Thyroid. Thyroid axis (diseases)
Thyrotropin - blood
Thyroxine - blood
Triiodothyronine - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Weight Gain - drug effects
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Description
Summary:Context: Radioiodine (RAI) therapy may cause progression of mild or absent Graves’ orbitopathy (GO), preventable by oral prednisone. Optimal doses of prednisone are undefined. Objective: The aim of this study was to compare the effectiveness of reported doses [starting dose, >0.3 mg/kg body weight (bw)], and lower (
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2009-2130