Liver disease in pregnancy

Summary Severe liver disease in pregnancy is rare. Pregnancy-related liver disease is the most frequent cause of liver dysfunction in pregnancy and provides a real threat to fetal and maternal survival. A rapid diagnosis differentiating between liver disease related and unrelated to pregnancy is req...

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Bibliographic Details
Published in:The Lancet (British edition) 2010-02, Vol.375 (9714), p.594-605
Main Authors: Joshi, Deepak, MRCP, James, Andra, MD, Quaglia, Alberto, FRCPath, Westbrook, Rachel H, MRCP, Heneghan, Michael A, Dr
Format: Article
Language:English
Subjects:
Acids
Anoxia
Bile
Biological and medical sciences
Cholestasis, Intrahepatic - diagnosis
Disease
Eclampsia - diagnosis
Fatty Liver - diagnosis
Female
Gallbladder diseases
General aspects
Genetics
HELLP Syndrome - diagnosis
Humans
Hyperemesis Gravidarum - diagnosis
Internal Medicine
Jaundice
Liver
Liver diseases
Liver Diseases - diagnosis
Liver Diseases - etiology
Liver Diseases - therapy
Liver Transplantation
Medical sciences
Mortality
Mutation
Pre-Eclampsia - diagnosis
Pregnancy
Pregnancy Complications - diagnosis
Pregnancy Complications - therapy
Pregnancy Outcome
Prognosis
Risk Factors
Womens health
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Summary:Summary Severe liver disease in pregnancy is rare. Pregnancy-related liver disease is the most frequent cause of liver dysfunction in pregnancy and provides a real threat to fetal and maternal survival. A rapid diagnosis differentiating between liver disease related and unrelated to pregnancy is required in women who present with liver dysfunction during pregnancy. Research has improved our understanding of the pathogenesis of pregnancy-related liver disease, which has translated into improved maternal and fetal outcomes. Here, we provide an overview of liver diseases that occur in pregnancy, an update on the key mechanisms involved in their pathogenesis, and assessment of available treatment options.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(09)61495-1