Effects of n-3 Polyunsaturated Fatty Acid Therapy on Plasma Inflammatory Markers and N-Terminal Pro-brain Natriuretic Peptide in Elderly Patients with Chronic Heart Failure

Several previous studies have suggested that n-3 polyunsaturated fatty acids (n-3 PUFA) can exert favourable effects in patients with heart failure, but the mechanisms involved are not fully understood. This study was designed to investigate the effects of n-3 PUFA on circulating inflammatory marker...

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Bibliographic Details
Published in:Journal of international medical research 2009-11, Vol.37 (6), p.1831-1841
Main Authors: Zhao, YT, Shao, L, Teng, LL, Hu, B, Luo, Y, Yu, X, Zhang, DF, Zhang, H
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
C-Reactive Protein - metabolism
Chronic Disease
Fatty Acids, Omega-3 - therapeutic use
Female
Heart Failure - blood
Heart Failure - complications
Heart Failure - drug therapy
Humans
Inflammation - blood
Inflammation - complications
Male
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Placebos
Smoking - adverse effects
Smoking - blood
Time Factors
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Summary:Several previous studies have suggested that n-3 polyunsaturated fatty acids (n-3 PUFA) can exert favourable effects in patients with heart failure, but the mechanisms involved are not fully understood. This study was designed to investigate the effects of n-3 PUFA on circulating inflammatory markers and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with heart failure. Seventy-six patients with heart failure were randomly assigned to receive 2 g/day of n-3 PUFA or placebo for 3 months. Treatment with n-3 PUFA significantly decreased plasma levels of tumour necrosis factor, interleukin-6, intercellular adhesion molecule 1 and NT-proBNP. Left ventricular ejection fraction showed a small, non-significant improvement. High-sensitivity C-reactive protein levels decreased significantly in smokers after n-3 PUFA treatment. Thus, n-3 PUFA can reduce levels of plasma inflammatory markers and NT-proBNP as biomarkers of risk stratification in patients with heart failure. n-3 PUFA may offer a novel therapy for heart failure.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000903700619