T Cells Use Rafts for Survival

T cell homeostasis must be tightly controlled. In this issue of Immunity, Cho et al. (2010) describe results that begin to define the roles of the T cell receptor, self-peptide-MHC ligands, cytokines, and membrane rafts in this dynamic process.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2010-02, Vol.32 (2), p.145-147
Main Authors: Stone, Jennifer D., Kranz, David M.
Format: Article
Language:English
Subjects:
Animals
Antigens, CD - metabolism
Autoantigens - chemistry
Autoantigens - immunology
Autoantigens - metabolism
Cell Survival - immunology
Cytokines
Cytokines - immunology
Cytokines - metabolism
Histocompatibility Antigens - chemistry
Histocompatibility Antigens - immunology
Histocompatibility Antigens - metabolism
Ligands
Lipids
Lymphocyte Activation
Membrane Microdomains - immunology
Membrane Microdomains - metabolism
Mice
Peptide Fragments - chemistry
Peptide Fragments - immunology
Peptide Fragments - metabolism
Peptides
Protein Binding
Receptors, Antigen, T-Cell - chemistry
Receptors, Antigen, T-Cell - immunology
Receptors, Antigen, T-Cell - metabolism
Structure-Activity Relationship
T cell receptors
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
T-Lymphocytes - pathology
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Description
Summary:T cell homeostasis must be tightly controlled. In this issue of Immunity, Cho et al. (2010) describe results that begin to define the roles of the T cell receptor, self-peptide-MHC ligands, cytokines, and membrane rafts in this dynamic process.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2010.02.002