Effects of Chronic Treatment with Honokiol in Spontaneously Hypertensive Rats

The present study was performed to evaluate the antihypertensive effects of honokiol in vivo in spontaneously hypertensive rats (SHR). The effects of honokiol were investigated by determination of the blood pressure, vascular reactivity, oxidative parameters, and histologic change in the aorta. Long...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2010/03/01, Vol.33(3), pp.427-431
Main Authors: Zhang, Gen-Shui, Wang, Ru-Jun, Zhang, Hai-Ning, Zhang, Gui-Ping, Luo, Miao-Shan, Luo, Jian-Dong
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Antioxidants - pharmacology
Antioxidants - therapeutic use
aorta
Aorta - drug effects
Aorta - pathology
Biphenyl Compounds - pharmacology
Biphenyl Compounds - therapeutic use
Blood Pressure - drug effects
Elastin - metabolism
honokiol
hypertension
Hypertension - drug therapy
Lignans - pharmacology
Lignans - therapeutic use
Liver - metabolism
Magnolia - chemistry
Malondialdehyde - metabolism
Nitrates - blood
Nitrites - blood
Nitroprusside - pharmacology
oxidative stress
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats
Rats, Inbred SHR
spontaneously hypertensive rat
Vasodilator Agents - pharmacology
Vasodilator Agents - therapeutic use
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Summary:The present study was performed to evaluate the antihypertensive effects of honokiol in vivo in spontaneously hypertensive rats (SHR). The effects of honokiol were investigated by determination of the blood pressure, vascular reactivity, oxidative parameters, and histologic change in the aorta. Long-term administration of honokiol (400 mg/kg/d) to SHR decreased systolic blood pressure significantly. Honokiol (200, 400 mg/kg/d) enhanced the aortic relaxation in response to acetylcholine after 49-d treatment, but had no significant effects on the relaxation to sodium nitroprusside. The oral administration of honokiol significantly increased the plasma level of NO2−/NO3−, but decreased the level of malondialdehyde in liver of SHR compared with the control vehicle. In addition, SHR administered honokiol showed significant reductions in the elastin bands and media thickness in the aorta. These results suggest that chronic treatment with honokiol exerts an antihypertensive effect in SHR, and its vasorelaxant action and antioxidant properties may contribute to reducing the elevated blood pressure.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.33.427