Antioxidant Activity of Limonene on Normal Murine Lymphocytes: Relation to H2O2 Modulation and Cell Proliferation

:  Limonene is a monoterpene present in citrus fruit and is used as flavouring agents of foods. It was shown that monoterpenes possess antioxidant activity. Previously, it was demonstrated that limonene exerts anti‐proliferative action on a lymphoma cell line without modifying normal lymphocyte viab...

Full description

Saved in:
Bibliographic Details
Published in:Basic & clinical pharmacology & toxicology 2010-01, Vol.106 (1), p.38-44
Main Authors: Roberto, Davicino, Micucci, Patricia, Sebastian, Turner, Graciela, Ferraro, Anesini, Claudia
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - pharmacology
Cancer
Catalase
Cell proliferation
Cell Proliferation - drug effects
Citrus
Cyclohexenes - pharmacology
Enzymes
Flavorings
Food
Fruits
Hydrogen peroxide
Hydrogen Peroxide - metabolism
Hydrogen Peroxide - pharmacology
Limonene
Lymphocytes
Lymphocytes - drug effects
Lymphocytes - enzymology
Lymphoma
Male
Mice
Mice, Inbred BALB C
Mitochondria
Monoterpenes
Oxidative stress
Oxidative Stress - drug effects
Peroxidase
Superoxide dismutase
Terpenes - pharmacology
Tumor cell lines
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary::  Limonene is a monoterpene present in citrus fruit and is used as flavouring agents of foods. It was shown that monoterpenes possess antioxidant activity. Previously, it was demonstrated that limonene exerts anti‐proliferative action on a lymphoma cell line without modifying normal lymphocyte viability. H2O2 has a modulator role in cell proliferation. In the present study, the effect of limonene on normal lymphocytes proliferation and its relation with H2O2 level modulation was analysed, evaluating its effect on the activity of cell antioxidant enzymes, such as catalase, peroxidase and superoxide dismutase. Limonene exerted a biphasic effect on cell proliferation; the increase in cell proliferation was related to the decrease in H2O2 level by the increase in catalase and peroxidase activities. Moreover, limonene protected the cells to the oxidative stress induced by exogenous addition of H2O2. In view of these results, it is possible that limonene could protect normal lymphocytes from diseases related to oxidative stress, including cancer, but further research is necessary to establish the role of limonene as a potential antioxidant that can effectively protect lymphocytes from oxidative stress and mitochondrial dysfunction.
ISSN:1742-7835
1742-7843
DOI:10.1111/j.1742-7843.2009.00467.x