Catalytic Asymmetric Total Synthesis of Tangutorine

The first enantioselective total synthesis of tangutorine has been achieved, wherein a Pd-catalyzed asymmetric allylic amination using a chiral diaminophosphine oxide (DIAPHOX) preligand was the key step.

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Bibliographic Details
Published in:Organic letters 2010-02, Vol.12 (4), p.872-875
Main Authors: Nemoto, Tetsuhiro, Yamamoto, Eri, Franzén, Robert, Fukuyama, Takashi, Wu, Riliga, Fukamachi, Toshihiko, Kobayashi, Hiroshi, Hamada, Yasumasa
Format: Article
Language:English
Subjects:
Allyl Compounds - chemistry
Amination
Carbolines - chemical synthesis
Carbolines - chemistry
Catalysis
Drugs, Chinese Herbal - chemical synthesis
Drugs, Chinese Herbal - chemistry
Molecular Structure
Palladium - chemistry
Quinolizines - chemical synthesis
Quinolizines - chemistry
Stereoisomerism
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Description
Summary:The first enantioselective total synthesis of tangutorine has been achieved, wherein a Pd-catalyzed asymmetric allylic amination using a chiral diaminophosphine oxide (DIAPHOX) preligand was the key step.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol902929a