Intestinal Permeability in Irritable Bowel Syndrome Patients: Effects of NSAIDs

• Published in: Digestive diseases and sciences 2010-03, Vol.55 (3), p.716-723
• Main Authors: Kerckhoffs, Angèle P. M, Akkermans, Louis M. A, de Smet, Martin B. M, Besselink, Marc G. H, Hietbrink, Falco, Bartelink, Imke H, Busschers, Wim B, Samsom, Melvin, Renooij, Willem
• Format: Article
• Language: English
• Subjects: Adult; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Biochemistry; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Ethylenediaminetetraacetic acid; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Hepatology; Humans; Intestinal Mucosa - drug effects; Irritable bowel syndrome; Irritable Bowel Syndrome - drug therapy; Irritable Bowel Syndrome - physiopathology; Male; Medical research; Medical sciences; Medicine; Medicine & Public Health; Medicine, Experimental; Middle Aged; Nonsteroidal anti-inflammatory drugs; Oncology; Original Article; Other diseases. Semiology; Permeability; Permeability - drug effects; Pharmacology. Drug treatments; Polyethylene glycol; Polyethylene Glycols; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Transplant Surgery; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-009-0765-9

Intestinal permeability and the effect of NSAIDs on permeability were investigated in 14 irritable bowel syndrome (IBS) patients and 15 healthy subjects. In the study, 24-h urinary recoveries of orally administered polyethylene glycols (PEGs 400, 1500, and 4000) were not significantly different in healthy subjects and IBS patients before or after NSAID ingestion. Lactulose mannitol ratios in healthy subjects and IBS patients were not significantly different. Only time-dependent monitoring of PEG excretion showed that NSAIDs enhanced intestinal permeability for PEG 4000 in healthy subjects (P = 0.050) and for PEGs 400, 1500, and 4000 in IBS patients (P = 0.012, P = 0.041, and P = 0.012, respectively). These results show that intestinal permeability in IBS patients is not different from that in healthy subjects; NSAIDs compromise intestinal permeability in IBS patients to a greater extent than in healthy subjects, which suggests that IBS is associated with an altered response of the intestinal barrier to noxious agents.