NLRP3 inflammasome, a target for therapy in diverse disease states

A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin-associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout...

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Bibliographic Details
Published in:European journal of immunology 2010-03, Vol.40 (3), p.631-634
Main Authors: Cook, Graham P, Savic, Sinisa, Wittmann, Miriam, McDermott, Michael F
Format: Article
Language:English
Subjects:
Animals
Autoimmune Diseases - immunology
Autoinflammatory
Cancer
Carrier Proteins - immunology
Dermatitis, Contact - immunology
Diabetes Mellitus, Type 2 - immunology
Humans
IL‐1 inhibition
Immunity, Innate
Inflammasome
Inflammation - immunology
Liver
Multiprotein Complexes - immunology
Neoplasms - immunology
NLR Family, Pyrin Domain-Containing 3 Protein
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Summary:A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin-associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. Despite diverse pathologies, the central role of the inflammasome in innate defences and tumour elimination suggests common therapeutic approaches to reduce inflammation where appropriate.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.200940162