Finite Element Model of the Patched Human Carotid

Introduction: The hemodynamic effects of carotid artery patching are not well known. Our objective was to develop a fluid-solid finite element model of the endarterectomized and patched carotid artery. Methods: Hyperelastic materials parameters were determined from studies of 8 cadaveric carotids. B...

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Bibliographic Details
Published in:Vascular and endovascular surgery 2009-12, Vol.43 (6), p.533-541
Main Authors: Kamenskiy, Alexey V., Pipinos, Iraklis I., Desyatova, Anastasia S., Salkovskiy, Yuriy E., Yu Kossovich, Leonid, Kirillova, Irina V., Bockeria, Leo A., Morozov, Konstantin M., Polyaev, Vasiliy O., Lynch, Thomas G., Dzenis, Yuris A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomechanical Phenomena
Blood Flow Velocity
Cadaver
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Carotid Arteries - surgery
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - physiopathology
Carotid Stenosis - surgery
Elasticity
Endarterectomy, Carotid - instrumentation
Female
Finite Element Analysis
Hemodynamics
Humans
Male
Middle Aged
Models, Cardiovascular
Polytetrafluoroethylene
Regional Blood Flow
Stress, Mechanical
Tomography, X-Ray Computed
Ultrasonography, Doppler, Duplex
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Summary:Introduction: The hemodynamic effects of carotid artery patching are not well known. Our objective was to develop a fluid-solid finite element model of the endarterectomized and patched carotid artery. Methods: Hyperelastic materials parameters were determined from studies of 8 cadaveric carotids. Blood flow characteristics were based on intraoperative data from a patient undergoing endarterectomy. Wall shear stress, cyclic strain and effective stress were computed as hemodynamic parameters with known association with endothelial injury, neointimal hyperplasia abd atherogenesis. Results: Low wall shear stress, high cyclic strain and high effective stress were identified diffusely in the carotid bulb, at the margins around the patch and in the flow divider. Conclusion: Endarterectomy and Polytetrafluoroethylene patching produce considerable abnormalities in the hemodynamics of the repaired carotid. Advanced mechanical modeling can be used to evaluate different carotid revascularization approaches to obtain optimized biomechanical and hemodynamic results for the care of patients with carotid bifurcation disease.
ISSN:1538-5744
1938-9116
DOI:10.1177/1538574409345030