Chiral discrimination of alpha-amino acids with a C(2)-symmetric homoditopic receptor

Chiral discrimination of alpha-amino acids has been realized by a C(2)-symmetric homoditopic receptor, which is based on a binaphthyl chiral skeleton with 2,2'diisopropoxy substituents and a common binding side arm, (o-carboxamido)-trifluoroacetophenone moiety, in the 3,3'-positions, which...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2010-01, Vol.46 (4), p.541-543
Main Authors: Sambasivan, Sunderraman, Kim, Dae-Sik, Ahn, Kyo Han
Format: Article
Language:English
Subjects:
Acetophenones - chemistry
Amino Acids - chemistry
Binding Sites
Molecular Structure
Naphthalenes - chemistry
Stereoisomerism
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Summary:Chiral discrimination of alpha-amino acids has been realized by a C(2)-symmetric homoditopic receptor, which is based on a binaphthyl chiral skeleton with 2,2'diisopropoxy substituents and a common binding side arm, (o-carboxamido)-trifluoroacetophenone moiety, in the 3,3'-positions, which recognizes alpha-amino acids as their amino carboxylate forms through formation of stabilized adducts.
ISSN:1364-548X
DOI:10.1039/b919957h