Real-time monitoring of drug release

A new prodrug system, assembled using a distinctive coumarin linker, was demonstrated to report real-time activation and drug release in vitro.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2010-01, Vol.46 (4), p.553-555
Main Authors: Weinstain, Roy, Segal, Ehud, Satchi-Fainaro, Ronit, Shabat, Doron
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Alkylating - administration & dosage
Antineoplastic Agents, Alkylating - pharmacology
Cell Line, Tumor
Cell Survival - drug effects
Coumarins - chemical synthesis
Coumarins - chemistry
Drug Delivery Systems
Humans
Melphalan - administration & dosage
Melphalan - pharmacology
Molecular Structure
Prodrugs - chemical synthesis
Prodrugs - chemistry
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Description
Summary:A new prodrug system, assembled using a distinctive coumarin linker, was demonstrated to report real-time activation and drug release in vitro.
ISSN:1359-7345
1364-548X
DOI:10.1039/b919329d