Femtomolar detection of 2,4-dichlorophenoxyacetic acid herbicides via competitive immunoassays using microfluidic based carbon nanotube liquid gated transistor

Monitoring of environmental pollutants has become increasingly important due to concern over potential health and environmental impact inflicted by these chemicals. In this contribution, we focus on the development of an all-plastic biosensor comprising laminated single-walled carbon nanotubes as th...

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Bibliographic Details
Published in:Lab on a chip 2010-03, Vol.10 (5), p.634-638
Main Authors: Wijaya, I Putu Mahendra, Nie, Tey Ju, Gandhi, Sonu, Boro, Robin, Palaniappan, Alagappan, Hau, Goh Wei, Rodriguez, Isabel, Suri, C Raman, Mhaisalkar, Subodh G
Format: Article
Language:English
Subjects:
2,4-Dichlorophenoxyacetic Acid - analysis
Environmental Monitoring - instrumentation
Equipment Design
Equipment Failure Analysis
Herbicides - analysis
Immunoassay - instrumentation
Microchemistry - instrumentation
Microfluidics - instrumentation
Nanotechnology - instrumentation
Nanotubes, Carbon - chemistry
Nanotubes, Carbon - ultrastructure
Reproducibility of Results
Sensitivity and Specificity
Soil Pollutants - analysis
Solutions - chemistry
Transistors, Electronic
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Summary:Monitoring of environmental pollutants has become increasingly important due to concern over potential health and environmental impact inflicted by these chemicals. In this contribution, we focus on the development of an all-plastic biosensor comprising laminated single-walled carbon nanotubes as the active element and its conductance modulation in a liquid-gated field effect transistor, as the principle of transduction, for the detection of 2,4-dicholorophenoxy acetic acid (2,4-D) herbicide. The reported biosensor is capable of performing real-time label-free detection of analytes in liquid environment. This biosensor which relies on immunoassay principle for specificity is able to detect down to 500 fM levels of 2,4-D in soil samples.
ISSN:1473-0197
DOI:10.1039/b918566f