Parameters of the Cytokine System Functioning in Laboratory Primates

The cytokine status (IFN, IL, etc.) of different monkey species (M. mulatta, P. hamadryas, C. aethiops) was studied. The interferon status is determined by the following parameters: IFN content in circulating blood and production of IFN-α and IFN-γ by lymphocytes after appropriate in vitro induction...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-08, Vol.148 (2), p.250-252, Article 250
Main Authors: Agrba, V. Z, Lapin, B. A, Mezentseva, M. V, Karal-ogly, D. D, Surgutcheva, I. M, Ignatova, I. E, Sherbenko, V. E, Agumava, A. A, Aphanasiev, N. A
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Blood cells
Cell Biology
Cercopithecus aethiops - blood
cytokines
Cytokines - blood
Immune system
interferon status
Interferon-alpha - blood
Interferon-gamma - blood
interferon-α
interferon-γ
Internal Medicine
Laboratory Medicine
Lymphocytes
Macaca mulatta - blood
Papio - blood
Pathology
Primates
Primates - blood
Primatology
α-Interferon
γ-Interferon
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Summary:The cytokine status (IFN, IL, etc.) of different monkey species (M. mulatta, P. hamadryas, C. aethiops) was studied. The interferon status is determined by the following parameters: IFN content in circulating blood and production of IFN-α and IFN-γ by lymphocytes after appropriate in vitro induction. The interferon status of monkeys is similar to that of humans. The capacity to produce IFN reduces with age. It was found that genes of virtually all studied cytokines are expressed in blood cells and hence, in immune system cells.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0708-7