Inherited defects in pedigree dogs. Part 2: Disorders that are not related to breed standards

Recent debate concerning health problems in pedigree animals has highlighted gaps in current knowledge of the prevalence, severity and welfare implications of deleterious inherited traits within the pedigree-dog population. In this second part of a two-part review, inherited disorders in the top 50...

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Bibliographic Details
Published in:The veterinary journal (1997) 2010-01, Vol.183 (1), p.39-45
Main Authors: Summers, Jennifer F., Diesel, Gillian, Asher, Lucy, McGreevy, Paul D., Collins, Lisa M.
Format: Article
Language:English
Subjects:
Animal Welfare
Animals
Breed
Breeding - methods
Dog
Dog Diseases - epidemiology
Dog Diseases - genetics
Dog Diseases - pathology
Dogs - genetics
Female
Genes, Recessive
Genetic
Genetic Predisposition to Disease
Genetic Variation
Inbreeding
Inherited
Male
Pedigree
Prevalence
Recessive disorder
Severity of Illness Index
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Summary:Recent debate concerning health problems in pedigree animals has highlighted gaps in current knowledge of the prevalence, severity and welfare implications of deleterious inherited traits within the pedigree-dog population. In this second part of a two-part review, inherited disorders in the top 50 UK Kennel Club registered breeds were researched using systematic searches of existing databases. A set of inclusion and exclusion criteria, including an evidence strength scale (SEHB), were applied to search results. A total of 312 non-conformation linked inherited disorders was identified, with German shepherd dogs and Golden retrievers associated with the greatest number of disorders. The most commonly reported mode of inheritance was autosomal recessive (71%; 57 breed-disorder combinations), and the most common primarily affected body system was the nervous sensory system. To provide a true assessment of the scale of inherited disorders in the pedigree dogs studied more effort is required to collect accurate prevalence data.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2009.11.002