Agricultural-related chemical exposures, season of conception, and risk of gastroschisis in Washington State

Objective We sought to determine if periconceptional exposure to agrichemicals was associated with the development of gastroschisis. Study Design We conducted a retrospective, case-controlled study using Washington State Birth Certificate and US Geological Survey databases. Cases included all live-b...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2010-03, Vol.202 (3), p.241.e1-241.e6
Main Authors: Waller, Sarah A., MD, Paul, Kathleen, MPH, Peterson, Suzanne E., MD, Hitti, Jane E., MD, MPH
Format: Article
Language:English
Subjects:
abdominal wall defect
Adolescent
Adult
atrazine
Atrazine - toxicity
Biological and medical sciences
Case-Control Studies
Female
Fertilization
gastroschisis
Gastroschisis - epidemiology
Gynecology. Andrology. Obstetrics
herbicide
Herbicides - toxicity
Humans
Infant
Infant, Newborn
Maternal Exposure - adverse effects
Maternal Exposure - statistics & numerical data
Medical sciences
Middle Aged
Multivariate Analysis
Obstetrics and Gynecology
Parity
Pregnancy
Residence Characteristics
Retrospective Studies
Risk Assessment
Seasons
Smoking - epidemiology
Washington - epidemiology
Water Pollutants, Chemical - toxicity
Young Adult
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Summary:Objective We sought to determine if periconceptional exposure to agrichemicals was associated with the development of gastroschisis. Study Design We conducted a retrospective, case-controlled study using Washington State Birth Certificate and US Geological Survey databases. Cases included all live-born singleton infants with gastroschisis. Distance between a woman's residence and site of elevated exposure to agrichemicals was calculated. Multivariate regression was used to estimate the association between surface water concentrations of agrichemicals and the risk of gastroschisis. Results Eight hundred five cases and 3616 control subjects were identified. Gastroschisis occurred more frequently among those who resided
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2010.01.023