Observed and Predicted Growth Responses in Prepubertal Children with Growth Disorders: Guidance of Growth Hormone Treatment by Empirical Variables

• Published in: The journal of clinical endocrinology and metabolism 2010-03, Vol.95 (3), p.1229-1237
• Main Authors: Ranke, Michael B, Lindberg, Anders
• Format: Article
• Language: English
• Subjects: Adolescent; Age Factors; Algorithms; Anthropometry; Biological and medical sciences; Child; Child Development - physiology; Child, Preschool; Cross-Sectional Studies; Endocrinopathies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Growth Disorders - therapy; Human Growth Hormone - deficiency; Human Growth Hormone - therapeutic use; Humans; Infant; Infant, Newborn; Infant, Small for Gestational Age - growth & development; Male; Medical sciences; Models, Biological; Recombinant Proteins - therapeutic use; Severity of Illness Index; Treatment Outcome; Turner Syndrome - therapy; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2009-1471

Context: Information about the expected growth response of children to GH therapy is currently inadequate. Objectives: The aim of the study was to compare observed and expected growth in response to GH in prepubertal children and to propose how these parameters can be used to optimize GH therapy. Indices considered were observed growth, observed growth relative to reference data [height sd score (Ht SDS), change in (Δ) Ht SDS, height velocity (HV)], and observed growth relative to growth predicted from prediction models [Studentized residual (SR)]. Design/Setting/Patients/Intervention: Growth data from KIGS—Pfizer International Growth Database—on prepubertal children aged 1–13 yr with severe GH deficiency (GHD; maxGH