Comparison among different insulin sensitivity indices in obese patients

Aims Recently, several indices have been proposed for the measurement of insulin sensitivity (IS). We set out to make a comparison between fasting insulin, and different IS indices in obese subjects. Patients and methods Fasting and post load (75 g) glucose and insulin were measured in a consecutive...

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Bibliographic Details
Published in:Diabetic medicine 2003-06, Vol.20 (6), p.462-466
Main Authors: Mannucci, E., Bardini, G., Rotella, F., Rotella, C. M.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Glucose - analysis
Cholesterol, HDL - blood
Diabetes Mellitus - blood
Fasting - metabolism
Female
glucose
Humans
Hyperinsulinism - blood
Hyperinsulinism - diagnosis
Hypertension - blood
Hypertension - diagnosis
Hypertriglyceridemia - blood
Hypertriglyceridemia - diagnosis
insulin
Insulin - blood
insulin resistance
Insulin Resistance - physiology
Male
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Risk Factors
Triglycerides - blood
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Summary:Aims Recently, several indices have been proposed for the measurement of insulin sensitivity (IS). We set out to make a comparison between fasting insulin, and different IS indices in obese subjects. Patients and methods Fasting and post load (75 g) glucose and insulin were measured in a consecutive series of 767 (626 F, 141 M) obese (body mass index > 30 kg/m2) out‐patients, with no known history of diabetes (DM). Mean (± sd) age was 46.7 ± 13.8 years in females and 45.6 ± 14.3 years in males. Indices of IS based on fasting homeostasis assessment model (HOMA) and post‐load (ISI) glucose and insulin and either parameter (1A, and 1B scores) were determined. Results DM was diagnosed in 21.4% of females, and 20.6% of males, and impaired glucose tolerance in 24% females and 21.3% males. Fasting and post‐load glucose, triglyceride and HDL‐cholesterol were correlated with all indices in both sexes (P 
ISSN:0742-3071
1464-5491
DOI:10.1046/j.1464-5491.2003.00935.x