Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure

Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined...

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Bibliographic Details
Published in:Stroke (1970) 2003-06, Vol.34 (6), p.e48-e50
Main Authors: Heo, Ji Hoe, Kim, Seo Hyun, Lee, Kyung Yul, Kim, Eun Hee, Chu, Chong Kyu, Nam, Jeong Mo
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Aged, 80 and over
Cerebral Hemorrhage - blood
Cerebral Hemorrhage - enzymology
Drug Administration Routes
Drug Resistance
Female
Humans
Male
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 9 - blood
Middle Aged
Predictive Value of Tests
Prospective Studies
Reference Values
Risk Factors
Stroke - blood
Stroke - enzymology
Stroke - therapy
Thrombolytic Therapy
Tissue Plasminogen Activator - administration & dosage
Treatment Failure
Treatment Outcome
Urokinase-Type Plasminogen Activator - administration & dosage
Vascular Patency - drug effects
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Summary:Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography. The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized. MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000073788.81170.1C