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Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure
Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined...
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| Published in: | Stroke (1970) 2003-06, Vol.34 (6), p.e48-e50 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c459t-dbb7ec591db0263476c42eeb135f258e3ce09ee880977c7dc6b0ffca4b57df8c3 |
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| cites | cdi_FETCH-LOGICAL-c459t-dbb7ec591db0263476c42eeb135f258e3ce09ee880977c7dc6b0ffca4b57df8c3 |
| container_end_page | e50 |
| container_issue | 6 |
| container_start_page | e48 |
| container_title | Stroke (1970) |
| container_volume | 34 |
| creator | Heo, Ji Hoe Kim, Seo Hyun Lee, Kyung Yul Kim, Eun Hee Chu, Chong Kyu Nam, Jeong Mo |
| description | Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients.
Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography.
The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized.
MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus. |
| doi_str_mv | 10.1161/01.STR.0000073788.81170.1C |
| format | article |
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Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography.
The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized.
MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000073788.81170.1C</identifier><identifier>PMID: 12750540</identifier><language>eng</language><publisher>United States</publisher><subject>Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Cerebral Hemorrhage - blood ; Cerebral Hemorrhage - enzymology ; Drug Administration Routes ; Drug Resistance ; Female ; Humans ; Male ; Matrix Metalloproteinase 2 - blood ; Matrix Metalloproteinase 9 - blood ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Reference Values ; Risk Factors ; Stroke - blood ; Stroke - enzymology ; Stroke - therapy ; Thrombolytic Therapy ; Tissue Plasminogen Activator - administration & dosage ; Treatment Failure ; Treatment Outcome ; Urokinase-Type Plasminogen Activator - administration & dosage ; Vascular Patency - drug effects</subject><ispartof>Stroke (1970), 2003-06, Vol.34 (6), p.e48-e50</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-dbb7ec591db0263476c42eeb135f258e3ce09ee880977c7dc6b0ffca4b57df8c3</citedby><cites>FETCH-LOGICAL-c459t-dbb7ec591db0263476c42eeb135f258e3ce09ee880977c7dc6b0ffca4b57df8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12750540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heo, Ji Hoe</creatorcontrib><creatorcontrib>Kim, Seo Hyun</creatorcontrib><creatorcontrib>Lee, Kyung Yul</creatorcontrib><creatorcontrib>Kim, Eun Hee</creatorcontrib><creatorcontrib>Chu, Chong Kyu</creatorcontrib><creatorcontrib>Nam, Jeong Mo</creatorcontrib><title>Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients.
Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography.
The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized.
MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cerebral Hemorrhage - blood</subject><subject>Cerebral Hemorrhage - enzymology</subject><subject>Drug Administration Routes</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - blood</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Risk Factors</subject><subject>Stroke - blood</subject><subject>Stroke - enzymology</subject><subject>Stroke - therapy</subject><subject>Thrombolytic Therapy</subject><subject>Tissue Plasminogen Activator - administration & dosage</subject><subject>Treatment Failure</subject><subject>Treatment Outcome</subject><subject>Urokinase-Type Plasminogen Activator - administration & dosage</subject><subject>Vascular Patency - drug effects</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpFkE1LAzEQhoMotlb_ggQP3rYmm2ST9SbFj0JB0HqO2ewsje6XSRbtv3drC85lDvO8M8OD0BUlc0ozekPo_HX9Mie7kkwqNVeUynG4OEJTKlKe8CxVx2hKCMuTlOf5BJ2F8DHiKVPiFE1oKgURnEzR-7K1HkwA7Frc1yY0BjcmeveDG4imrrvedxFcOyJJvoOMHSLgEH33Cbg30UEbA_52cYPjxndN0dXb4AKujKsHD-fopDJ1gItDn6G3h_v14ilZPT8uF3erxHKRx6QsCglW5LQsSJoxLjPLU4CCMlGlQgGzQHIApUgupZWlzQpSVdbwQsiyUpbN0PV-7_jv1wAh6sYFC3VtWuiGoCVjkhLGR_B2D1rfheCh0r13jfFbTYne-dWE6tGv_ver__xquhjDl4crQ9FA-R89CGW_dKd5sg</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Heo, Ji Hoe</creator><creator>Kim, Seo Hyun</creator><creator>Lee, Kyung Yul</creator><creator>Kim, Eun Hee</creator><creator>Chu, Chong Kyu</creator><creator>Nam, Jeong Mo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure</title><author>Heo, Ji Hoe ; Kim, Seo Hyun ; Lee, Kyung Yul ; Kim, Eun Hee ; Chu, Chong Kyu ; Nam, Jeong Mo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-dbb7ec591db0263476c42eeb135f258e3ce09ee880977c7dc6b0ffca4b57df8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cerebral Hemorrhage - blood</topic><topic>Cerebral Hemorrhage - enzymology</topic><topic>Drug Administration Routes</topic><topic>Drug Resistance</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - blood</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Risk Factors</topic><topic>Stroke - blood</topic><topic>Stroke - enzymology</topic><topic>Stroke - therapy</topic><topic>Thrombolytic Therapy</topic><topic>Tissue Plasminogen Activator - administration & dosage</topic><topic>Treatment Failure</topic><topic>Treatment Outcome</topic><topic>Urokinase-Type Plasminogen Activator - administration & dosage</topic><topic>Vascular Patency - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heo, Ji Hoe</creatorcontrib><creatorcontrib>Kim, Seo Hyun</creatorcontrib><creatorcontrib>Lee, Kyung Yul</creatorcontrib><creatorcontrib>Kim, Eun Hee</creatorcontrib><creatorcontrib>Chu, Chong Kyu</creatorcontrib><creatorcontrib>Nam, Jeong Mo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heo, Ji Hoe</au><au>Kim, Seo Hyun</au><au>Lee, Kyung Yul</au><au>Kim, Eun Hee</au><au>Chu, Chong Kyu</au><au>Nam, Jeong Mo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>34</volume><issue>6</issue><spage>e48</spage><epage>e50</epage><pages>e48-e50</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><abstract>Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients.
Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography.
The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized.
MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.</abstract><cop>United States</cop><pmid>12750540</pmid><doi>10.1161/01.STR.0000073788.81170.1C</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0039-2499 |
| ispartof | Stroke (1970), 2003-06, Vol.34 (6), p.e48-e50 |
| issn | 0039-2499 1524-4628 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73371034 |
| source | Alma/SFX Local Collection |
| subjects | Acute Disease Adult Aged Aged, 80 and over Cerebral Hemorrhage - blood Cerebral Hemorrhage - enzymology Drug Administration Routes Drug Resistance Female Humans Male Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 9 - blood Middle Aged Predictive Value of Tests Prospective Studies Reference Values Risk Factors Stroke - blood Stroke - enzymology Stroke - therapy Thrombolytic Therapy Tissue Plasminogen Activator - administration & dosage Treatment Failure Treatment Outcome Urokinase-Type Plasminogen Activator - administration & dosage Vascular Patency - drug effects |
| title | Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure |
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