Low serum total thyroxine and free triiodothyronine in patients with hepatic encephalopathy due to non-alcoholic cirrhosis

We evaluated serum thyroid hormone levels in non-alcoholic cirrhotic patients with and without hepatic encephalopathy. 15 consecutive patients with hepatic encephalopathy secondary to non-alcoholic cirrhosis (8 males and 7 females, age 37-75 years) and 33 non-alcoholic cirrhotic patients without enc...

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Bibliographic Details
Published in:Swiss medical weekly 2003-04, Vol.133 (13-14), p.210-213
Main Authors: Kayacetin, Ertuğrul, Kisakol, Gurcan, Kaya, Ahmet
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Hepatic Encephalopathy - blood
Hepatic Encephalopathy - etiology
Hepatic Encephalopathy - physiopathology
Humans
Liver Cirrhosis - blood
Liver Cirrhosis - complications
Liver Cirrhosis - physiopathology
Male
Middle Aged
Prothrombin Time
Risk Factors
Severity of Illness Index
Thyroid Diseases - blood
Thyroid Diseases - etiology
Thyroid Diseases - physiopathology
Thyroid Function Tests
Thyroxine - blood
Triiodothyronine - blood
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Summary:We evaluated serum thyroid hormone levels in non-alcoholic cirrhotic patients with and without hepatic encephalopathy. 15 consecutive patients with hepatic encephalopathy secondary to non-alcoholic cirrhosis (8 males and 7 females, age 37-75 years) and 33 non-alcoholic cirrhotic patients without encephalopathy (22 males and 11 females, age 36-74 years) were investigated. A control group consisted of 20 healthy subjects (10 men and 10 women aged 26-69 years). The levels of serum triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH), free T3 (FT3) and free T4 (FT4) were studied in serum samples drawn in the morning. Thyroid function tests were set in relation to the severity of hepatic dysfunction and to the presence or absence of hepatic encephalopathy. Serum levels of FT3 and total T4 (but not total T3 and FT4) were significantly lower in patients with hepatic encephalopathy compared to decompensated cirrhotic patients without encephalopathy (p = 0.006 for T4, P
ISSN:1424-7860