Cerebral sinovenous thrombosis in children: Clinical presentation and extension, localization and recanalization of thrombosis

Abstract Many important questions regarding pathophysiology and treatment of cerebral sinovenous thrombosis need clarification and may depend on further knowledge on the etiology, site, extension and recanalization of the thrombosis. We studied these variables in a cohort of children and adolescents...

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Bibliographic Details
Published in:European journal of paediatric neurology 2010-01, Vol.14 (1), p.80-85
Main Authors: Vieira, J.P, Luis, C, Monteiro, J.P, Temudo, T, Campos, M.M, Quintas, S, Nunes, S
Format: Article
Language:English
Subjects:
Adolescent
Anticoagulants - therapeutic use
Cerebral sinovenous thrombosis
Child
Child, Preschool
Cohort Studies
Female
Humans
Infant
Infant, Newborn
Intracranial Thrombosis - complications
Intracranial Thrombosis - diagnosis
Intracranial Thrombosis - epidemiology
Intracranial Thrombosis - therapy
Magnetic Resonance Imaging
Male
Neurology
Pediatric stroke
Pediatrics
Recanalization cerebral sinovenous thrombosis
Retrospective Studies
Risk Factors
Sinus Thrombosis, Intracranial - complications
Sinus Thrombosis, Intracranial - diagnosis
Sinus Thrombosis, Intracranial - epidemiology
Sinus Thrombosis, Intracranial - therapy
Treatment Outcome
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Summary:Abstract Many important questions regarding pathophysiology and treatment of cerebral sinovenous thrombosis need clarification and may depend on further knowledge on the etiology, site, extension and recanalization of the thrombosis. We studied these variables in a cohort of children and adolescents from seven Portuguese Centers. We conclude from our results that the deep venous system and the superior longitudinal sinus are less frequently affected with thrombosis but have a greater potential for serious neurologic disease and for major sequelae. Non-recanalization, at least in the long term, is not an adverse prognostic factor. Extensive propagation of the thrombus from the initial site of origin seems to be common. The early identification of risk factors and their treatment coupled with an aggressive attitude towards diagnosis and treatment for thrombosis involving the deep venous system would be warranted.
ISSN:1090-3798
1532-2130
DOI:10.1016/j.ejpn.2008.12.004