Risk factors for thrombophilia in young adults presenting with thrombosis

The increased risk for thrombosis is known as hypercoagulability or thrombophilia. Here, we investigated risk factors for thrombophilia which were screened in young adult patients presenting with thrombotic events or with recurrent abortions with unknown etiology. A total of 115 patients aged betwee...

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Bibliographic Details
Published in:International journal of hematology 2009-12, Vol.90 (5), p.583-590
Main Authors: Yokus, Osman, Albayrak, Murat, Balcik, Ozlem Sahin, Ceran, Funda, Dagdas, Simten, Yilmaz, Mesude, Ozet, Gulsum
Format: Article
Language:English
Subjects:
Abortion, Habitual - etiology
Adolescent
Adult
Age Factors
Biological and medical sciences
Female
Hematologic and hematopoietic diseases
Hematology
Humans
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Platelet diseases and coagulopathies
Pregnancy
Retrospective Studies
Risk Factors
Thrombophilia - blood
Thrombophilia - complications
Thrombophilia - genetics
Thrombosis - blood
Thrombosis - etiology
Thrombosis - genetics
Young Adult
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Summary:The increased risk for thrombosis is known as hypercoagulability or thrombophilia. Here, we investigated risk factors for thrombophilia which were screened in young adult patients presenting with thrombotic events or with recurrent abortions with unknown etiology. A total of 115 patients aged between 16 and 50 years who were found to harbor thrombophilia were retrospectively evaluated. The laboratory investigations performed for the assessment of thrombophilia included protein C, protein S, antithrombin III deficiencies, activated protein C resistance, factor V Leiden (FVL), prothrombin 20210A (PT 20210) and methylenetetrahydrofolate reductase (MTHFR) gene mutations, factor VIII elevation, lupus anticoagulant and antiphospholipid antibodies (APA). In 66% of the cases a single thrombophilic defect was identified while some of the patients had combined thrombophilic defects. The most common thrombophilic defect was mutation in the MTHFR gene, and was followed by FVL mutation, the presence of APA and PT 20210 gene mutation, respectively. The patients were divided into two different age groups, 16–35 and 36–50 years, and arterial thrombosis was more common in the older age group. Our results indicated that some important thrombophilic defects such as gene mutations may appear in young adult patients presenting with thrombotic events.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-009-0447-6