Antioxidant and Anticholinesterase Activity Evaluation of ent-Kaurane Diterpenoids from Sideritis arguta

The petroleum ether and acetone extracts of the aerial parts of Sideritis arguta afforded two new and six known diterpenoids with the ent-kaurane skeleton. The structures of the new diterpenoids were determined as ent-7α,18-diacetoxy-16β-hydroxykaurane (diacetyldistanol) (1) and ent-7α-acetoxy,15α,1...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2009-03, Vol.72 (3), p.500-502
Main Authors: ERTAS, Abdülselam, OZTÜRK, Mehmet, BOGA, Mehmet, TOPCU, Gülacti
Format: Article
Language:English
Subjects:
Antioxidants - pharmacology
Biological and medical sciences
Cholinesterase Inhibitors - pharmacology
Diterpenes, Kaurane - chemistry
Diterpenes, Kaurane - isolation & purification
Diterpenes, Kaurane - pharmacology
General pharmacology
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Sideritis - chemistry
Stereoisomerism
Turkey
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Summary:The petroleum ether and acetone extracts of the aerial parts of Sideritis arguta afforded two new and six known diterpenoids with the ent-kaurane skeleton. The structures of the new diterpenoids were determined as ent-7α,18-diacetoxy-16β-hydroxykaurane (diacetyldistanol) (1) and ent-7α-acetoxy,15α,18-dihydroxykaur-16-ene (15-epi-eubol) (2) by spectroscopic data interpretation. Antioxidant potential was investigated for the ent-kauranes and the plant extracts by three methods (β-carotene bleaching, free-radical scavenging, and superoxide-anion scavenging activity). Acetylcholinesterase and butyrylcholinesterase inhibitory activity were also evaluated, and the ent-kauranes eubol (3), sideroxol (5), and 7-epi-candicandiol (6) exhibited moderate butyrylcholinesterase inhibitory activity.
ISSN:0163-3864
1520-6025
DOI:10.1021/np800671p