Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes

Linkage of chromosome 11q13 to type 1 diabetes (T1D) was first reported from genome scans (Davies et al. 1994; Hashimoto et al. 1994) resulting in P T. The disease association data, largely focused in the LRP5 region with 1,106 T1D families, provided no further evidence for disease association at LR...

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Published in:Human genetics 2003-07, Vol.113 (2), p.99-105
Main Authors: TWELLS, Rebecca C. J, MEIN, Charles A, RANCE, Helen E, CARR, Philippa, DUDBRIDGE, Frank, CORDELL, Heather J, COOPER, Jason, TUOMILEHTO-WOLF, Eva, TUOMILEHTO, Jaakko, PHILLIPS, Michael, METZKER, Michael, HESS, J. Fred, PAYNE, Felicity, TODD, John A, VEIJOLA, Riitta, GILBEY, Matthew, BRIGHT, Matthew, TIMMS, Andrew, NAKAGAWA, Yusuke, SNOOK, Hywel, NUTLAND, Sarah
Format: Article
Language:English
Subjects:
Biological and medical sciences
chromosome 11
Chromosome Mapping
Chromosomes, Human, Pair 11 - genetics
Diabetes Mellitus, Type 1 - genetics
Fundamental and applied biological sciences. Psychology
Genetic aspects
Genetic Linkage
Genomes
Genomics
Genotype
Humans
LDL-Receptor Related Proteins
lipoprotein (low-density) receptor-related protein
Low Density Lipoprotein Receptor-Related Protein-5
LRP5 gene
Microsatellite Repeats
Molecular and cellular biology
Receptors, LDL - genetics
Single nucleotide polymorphisms
Type 1 diabetes
Type 2 diabetes
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Summary:Linkage of chromosome 11q13 to type 1 diabetes (T1D) was first reported from genome scans (Davies et al. 1994; Hashimoto et al. 1994) resulting in P T. The disease association data, largely focused in the LRP5 region with 1,106 T1D families, provided no further evidence for disease association at LRP5 or at D11S987. A second dataset, comprising 1,569 families from Finland, failed to replicate our previous findings at LRP5. The continued search for the variants of the putative IDDM4 locus will greatly benefit from the future development of a haplotype map of the genome.
ISSN:0340-6717
1432-1203
DOI:10.1007/s00439-003-0940-6