Chiral discrimination of basic and hydrophobic molecules by chemical force spectroscopy

Chemical force spectroscopy (CFS) is becoming a powerful technique with which to measure intermolecular forces. The prime advantage over other techniques is the ability to map spatial distribution of ligands on the surface. We have used CFS to explore the binding force of a variety of different chir...

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Bibliographic Details
Published in:Ultramicroscopy 2003-10, Vol.97 (1), p.297-301
Main Authors: Mahapatro, Mrinal, Gibson, Christopher, Abell, Chris, Rayment, Trevor
Format: Article
Language:English
Subjects:
Atomic force microscopes
Biological and medical sciences
Chemical force spectroscopy
Chiral discrimination
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
General aspects, investigation technics, apparatus
Instruments, apparatus, components and techniques common to several branches of physics and astronomy
Physics
Scanning probe microscopes, components and techniques
Scanning tunneling and atomic force microscopy
Tissues, organs and organisms biophysics
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Summary:Chemical force spectroscopy (CFS) is becoming a powerful technique with which to measure intermolecular forces. The prime advantage over other techniques is the ability to map spatial distribution of ligands on the surface. We have used CFS to explore the binding force of a variety of different chiral molecules in order to understand more about the nature of what is a fundamental aspect of chemical biology and of central importance in pharmacology.
ISSN:0304-3991
1879-2723
DOI:10.1016/S0304-3991(03)00055-X