Subunit Mobility and the Chaperone Activity of Recombinant alphaB-Crystallin

The comparison of the chaperone-like activity of native and covalently cross-linked human alphaB-crystallins has confirmed the important role of the subunit mobility in the chaperoning mechanism. Our data clearly demonstrate that the chaperone-like activity of alpha-crystallin is not only a surface...

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Bibliographic Details
Published in:The open biochemistry journal 2008, Vol.2, p.116-120
Main Authors: Krushelnitsky, A, Mukhametshina, N, Gogolev, Y, Tarasova, N, Faizullin, D, Zinkevich, T, Gnezdilov, O, Fedotov, V
Format: Article
Language:English
Online Access:Get full text
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Summary:The comparison of the chaperone-like activity of native and covalently cross-linked human alphaB-crystallins has confirmed the important role of the subunit mobility in the chaperoning mechanism. Our data clearly demonstrate that the chaperone-like activity of alpha-crystallin is not only a surface phenomenon as was suggested by some researchers.
ISSN:1874-091X
DOI:10.2174/1874091X00802010116