Anti-dsDNA and Sm autoantibodies in systemic lupus erythematosus

During the present study the coincidence of anti-dsDNA and Sm antibodies was detected in 16 percent of 51 consecutive SLE patients. These antibodies were detected by the standard indirect immunofluorescence and Ouchterlony tests. All patients with anti-dsDNA and Sm antibodies showed disease activity...

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Bibliographic Details
Published in:Clinical rheumatology 1992-09, Vol.11 (3), p.341-345
Main Authors: Martínez-Cordero, E, Martínez-Miranda, E, Negrete-García, M C, Padilla, A, Aguilar León, D E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies, Antinuclear - analysis
Autoantibodies - analysis
Autoantibodies - immunology
Autoantigens - immunology
Cross Reactions
DNA - immunology
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique
Humans
Lupus Erythematosus, Systemic - immunology
Male
Middle Aged
Ribonucleoproteins, Small Nuclear
snRNP Core Proteins
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Summary:During the present study the coincidence of anti-dsDNA and Sm antibodies was detected in 16 percent of 51 consecutive SLE patients. These antibodies were detected by the standard indirect immunofluorescence and Ouchterlony tests. All patients with anti-dsDNA and Sm antibodies showed disease activity, including renal, CNS and pulmonary disease. We excluded a cross reactivity of these antibodies by ELISA, using competitive experiments with dsDNA and Sm antigens. The results support the presence of multiple autoantibody production during SLE activity, and suggest that different mechanisms may underlie the induction and regulation of both autoantibodies.
ISSN:0770-3198
1434-9949
DOI:10.1007/BF02207190