A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2003-06, Vol.42 (22), p.2507-2511
Main Authors: Olsen, Jacob A, Banner, David W, Seiler, Paul, Obst Sander, Ulrike, D'Arcy, Allan, Stihle, Martine, Müller, Klaus, Diederich, François
Format: Article
Language:English
Subjects:
Binding Sites
Crystallography, X-Ray
Fluorine - chemistry
Ligands
Models, Molecular
Molecular Structure
Serine Proteinase Inhibitors - chemistry
Serine Proteinase Inhibitors - metabolism
Stereoisomerism
Thrombin - antagonists & inhibitors
Thrombin - chemistry
Thrombin - metabolism
Trypsin - chemistry
Trypsin - metabolism
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ISSN:1433-7851