The development of hypercalcemia in a patient with an ovarian tumor producing parathyroid hormone‐related protein

Hypercalcemia developed in a 34‐year‐old woman with a clear cell carcinoma of the ovary. Osseous involvement with the tumor cells was not present. Primary hyperpara‐thyroidism was absent. Operative partial resection of the metastatic supraclavicular lymph node, followed by radiation therapy, decreas...

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Bibliographic Details
Published in:Cancer 1992-12, Vol.70 (12), p.2845-2850
Main Authors: Fujino, Toshinori, Watanabe, Tomoko, Yamaguchi, Ken, Nagasaki, Koichi, Onishi, Eishi, Iwamoto, Ichiro, Dozono, Haruhiko, Nagata, Yukihiro
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Adenocarcinoma - complications
Adenocarcinoma - metabolism
Adult
Biological and medical sciences
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
hypercalcemia
Hypercalcemia - etiology
Medical sciences
Ovarian Neoplasms - blood
Ovarian Neoplasms - complications
Ovarian Neoplasms - metabolism
ovarian tumor
Paraneoplastic Syndromes - etiology
paraneoplas‐tic syndrome
Parathyroid Hormone-Related Protein
Protein Biosynthesis
Tumors
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Summary:Hypercalcemia developed in a 34‐year‐old woman with a clear cell carcinoma of the ovary. Osseous involvement with the tumor cells was not present. Primary hyperpara‐thyroidism was absent. Operative partial resection of the metastatic supraclavicular lymph node, followed by radiation therapy, decreased her serum calcium concentrations. This case belongs to the category of humoral hypercalcemia of malignancy (HHM). Detection of a significant quantity of immunoreactive parathyroid hormone‐related protein (PTH‐rP) in the metastatic lymph node suggested that the HHM of the patient was induced by PTH‐rP produced by the tumor. From a review of 17 cases of ovarian tumors showing HHM‐like morbidity, it was found that clear cell carcinoma and cystadenocar‐cinoma were the major types of ovarian tumors associated with HHM.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19921215)70:12<2845::AID-CNCR2820701221>3.0.CO;2-F