Lipoprotein(a) Concentrations in Mexican Americans and Non-Hispanic Whites: The San Antonio Heart Study

There is considerable evidence that lipoprotein(a) (Lp(a)) is a strong independent risk factor for coronary heart disease. Based on their risk factor profile, Mexican Americans have an increased risk of coronary heart disease, yet Mexican Americans have coronary heart disease mortality similar to or...

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Bibliographic Details
Published in:American journal of epidemiology 1992-11, Vol.136 (9), p.1060-1068
Main Authors: Haffner, Steven M., Gruber, Katherine K., Morales, Philip A., Hazuda, Helen P., Valdez, Rodolfo A., Mitchell, Braxton D., Stem, Michael P.
Format: Article
Language:English
Subjects:
Adult
Aging - blood
Alcohol Drinking - blood
Biological and medical sciences
Blood Glucose - analysis
Body Constitution - physiology
Cardiology. Vascular system
coronary disease
Coronary heart disease
diabetes mellitus
European Continental Ancestry Group
Female
Heart
Hispanic Americans
Humans
Insulin - blood
Lipoprotein(a) - blood
lipoproteins
Male
Medical sciences
Mexican Americans
Mexico - ethnology
Middle Aged
Obesity - blood
Obesity - ethnology
Odds Ratio
Regression Analysis
Sex Factors
Smoking - blood
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Summary:There is considerable evidence that lipoprotein(a) (Lp(a)) is a strong independent risk factor for coronary heart disease. Based on their risk factor profile, Mexican Americans have an increased risk of coronary heart disease, yet Mexican Americans have coronary heart disease mortality similar to or lower than that of non-Hispanic whites. The authors therefore attempted to determine whether Mexican Americans had decreased Lp(a) concentrations relative to non-Hispanic whites in the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Lp(a) concentrations (mg/dl) were significantly lower in Mexican Americans (n = 316) than in non-Hispanic whites (n =242) (men: 10. 4 vs. 16. 3; women: 11. 5 vs. 16. 4). In addition, the proportion of persons with Lp(a) concentrations of ≥30 mg/dl (the threshold at which increased risk of coronary heart disease is believed to occur) was significantly higher in non-Hispanic whites than in Mexican Americans (18. 6% vs. 7. 6%; Mantel-Haenszel odds ratio (adjusted for sex) = 2. 79). Age, obesity, body fat distribution, cigarette smoking, alcohol consumption, and glucose and insulin concentrations were not significantly related to Lp(a) levels. Decreased Lp(a) concentrations may account in part for Mexican Americans‘ relative protection from coronary heart disease mortality. Am J Epidemiol 1992; 136: 1060–8
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a116571