Relation of Oxidative Biomarkers, Vascular Dysfunction, and Progression of Coronary Artery Calcium

• Published in: The American journal of cardiology 2010-02, Vol.105 (4), p.459-466
• Main Authors: Ahmadi, Naser, MD, Tsimikas, Sotirios, MD, Hajsadeghi, Fereshteh, MD, Saeed, Anila, MD, Nabavi, Vahid, MD, Bevinal, Manzoor A., MD, Kadakia, Jigar, MD, Flores, Ferdinand, MD, Ebrahimi, Ramin, MD, Budoff, Matthew J., MD
• Format: Article
• Language: English
• Subjects: Adult; Aged; Apolipoprotein B-100 - blood; Autoantibodies - blood; Biological and medical sciences; Biomarkers; Biomarkers - blood; Calcinosis - blood; Calcinosis - diagnostic imaging; Calcinosis - drug therapy; Calcinosis - physiopathology; Calcium; Calcium - blood; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cholesterol; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - drug therapy; Coronary Artery Disease - physiopathology; Coronary heart disease; Correlation analysis; Dietary Supplements; Disease Progression; Double-Blind Method; Equipment Design; Female; Fingers - blood supply; Follow-Up Studies; Garlic; Heart; Humans; Immunoglobulin G - blood; Immunoglobulin M - blood; Lipoprotein(a) - blood; Low density lipoprotein; Male; Medical sciences; Middle Aged; Oxidation; Oxidative Stress - drug effects; Phospholipids - blood; Phytotherapy; Plant Extracts - therapeutic use; Predictive Value of Tests; Radiography; Severity of Illness Index; Skin Temperature; Thermography - methods; Treatment Outcome; Vitamin B Complex - therapeutic use
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2009.09.052

The relation between oxidative stress and coronary artery calcium (CAC) progression is currently not well described. The present study evaluated the relation among the biomarkers of oxidative stress, vascular dysfunction, and CAC. Sixty asymptomatic subjects participated in a randomized trial evaluating the effect of aged garlic extract plus supplement versus placebo and underwent measurement of CAC. The postcuff deflation temperature-rebound index of vascular function was assessed using a reactive hyperemia procedure. The content of oxidized phospholipids (OxPL) on apolipoprotein B-100 (apoB) particles detected by antibody E06 (OxPL/apoB), lipoprotein(a), IgG and IgM autoantibodies to malondialdehyde–low-density lipoprotein and apoB-immune complexes were measured at baseline and after 12 months of treatment. CAC progression was defined as an annual increase in CAC >15%. Vascular dysfunction was defined according to the tertiles of temperature-rebound at 1 year of follow-up. From baseline to 12 months, a strong inverse correlation was noted between an increase in CAC scores and increases in temperature-rebound (r2 = −0.90), OxPL/apoB (r2 = −0.85), and lipoprotein(a) (r2 = −0.81) levels (p