The effects of continuous positive airway pressure on plasma brain natriuretic peptide concentrations in patients presenting with acute cardiogenic pulmonary edema with preserved left ventricular systolic function

• Published in: The American journal of emergency medicine 2010-02, Vol.28 (2), p.230-234
• Main Authors: Bellone, Andrea, MD, Etteri, Massimiliano, MD, Vettorello, Marco, MD, Berruti, Vittorio, MD, Maino, Carlo, MD, Mariani, Massimo, MD, Clerici, Dante, MD, Nessi, Italo, MD, Gini, Giancarlo, MD, Natalizi, Anna, MD, Brunati, Pietro, MD
• Format: Article
• Language: English
• Subjects: Acute Disease; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood pressure; Continuous Positive Airway Pressure; Edema; Emergency; Emergency and intensive respiratory care; Emergency medical care; Female; Heart attacks; Heart Diseases - therapy; Humans; Immunoassay; Intensive care medicine; Male; Medical sciences; Natriuretic Peptide, Brain - blood; Plasma; Prospective Studies; Protective equipment; Pulmonary Edema - therapy; Ventilation; Ventricular Function, Left
• ISSN: 0735-6757; 1532-8171
• DOI: 10.1016/j.ajem.2008.11.002

Abstract Background It has been established that plasma brain natriuretic peptide (BNP) concentrations in patients with acute cardiogenic pulmonary edema (ACPE) increase in proportion to heart failure. Objectives The aim of this study is to assess the effects of continuous positive airway pressure (CPAP) treatment on plasma BNP concentrations in patients presenting with ACPE with preserved left ventricular (LV) systolic function. Methods This was a prospective, observational single-center study in the emergency unit of Valduce Hospital. Twelve patients (group A) presenting with ACPE and preserved LV ejection fraction and 14 patients (group B) with systolic heart dysfunction (LV ejection fraction