Bisphosphonate-related osteonecrosis of the jaw presenting as a cutaneous dental sinus tract: A case report and review of the literature

Bisphosphonates are endogenous pyrophosphate analogs that work to inhibit osteoclast activity. They are commonly used in the treatment of patients with bone related diseases, such as solid tumor metastasis and osteoporosis. One of the infrequent but not rare side effects, especially with high doses...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2010-04, Vol.62 (4), p.672-676
Main Authors: Truong, Sam V., BS, Chang, Linda C., MD, Berger, Timothy G., MD
Format: Article
Language:English
Subjects:
Aged, 80 and over
Biological and medical sciences
Cutaneous Fistula - etiology
Dermatology
Diphosphonates - adverse effects
Diseases of the osteoarticular system
Female
Fistula - etiology
Humans
Jaw Diseases - chemically induced
Jaw Diseases - complications
Jaw Diseases - pathology
Medical sciences
Osteonecrosis - chemically induced
Osteonecrosis - complications
Periapical Diseases - etiology
Vascular bone diseases
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Summary:Bisphosphonates are endogenous pyrophosphate analogs that work to inhibit osteoclast activity. They are commonly used in the treatment of patients with bone related diseases, such as solid tumor metastasis and osteoporosis. One of the infrequent but not rare side effects, especially with high doses of bisphosphonates, is osteonecrosis of the jaw. Although predominantly recognized by dentists because of the bony and intraoral manifestations of the disease, it may also present on the skin. We present a case of osteonecrosis of the jaw resembling two flesh-colored papules associated with dental sinus tracts to highlight the clinical manifestations that dermatologists may encounter, and review the literature on this rare but morbid condition.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2008.09.021