Clinical Manifestations of Sinonasal Undifferentiated Carcinoma

Computed tomography (CT) of the sinuses demonstrated a large, enhancing mass within the left ethmoid sinus; CT also showed tumor erosion through the anterior cranial fossa and the left lamina papyracea and compression of the medial rectus muscle and optic nerve (figure 1). The high-grade nuclei in S...

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Bibliographic Details
Published in:Ear, nose, & throat journal nose, & throat journal, 2009-12, Vol.88 (12), p.1252-1254
Main Authors: Zandifar, Hootan, Hamilton, Jason S., Osborne, Ryan F., Kellman, Robert M.
Format: Article
Language:English
Subjects:
Adult
Antibiotics
Biopsy
Cancer
Carcinoma - complications
Carcinoma - pathology
Carcinoma - therapy
Care and treatment
Case studies
Chemotherapy
Combined Modality Therapy
CT imaging
Diagnosis
Endoscopy
Epistaxis - diagnosis
Epistaxis - etiology
Facial Pain - diagnosis
Facial Pain - etiology
Head and neck cancer
Health aspects
Humans
Laryngoscopy - methods
Male
Medical imaging
Nasal Obstruction - diagnosis
Nasal Obstruction - etiology
Nose
Paranasal Sinus Neoplasms - complications
Paranasal Sinus Neoplasms - pathology
Paranasal Sinus Neoplasms - therapy
Patient outcomes
Pharynx
Pressure
Risk factors
Sinuses
Skin & tissue grafts
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Description
Summary:Computed tomography (CT) of the sinuses demonstrated a large, enhancing mass within the left ethmoid sinus; CT also showed tumor erosion through the anterior cranial fossa and the left lamina papyracea and compression of the medial rectus muscle and optic nerve (figure 1). The high-grade nuclei in SNUC cells are relatively uniform, unlike those in nasopharyngeal carcinoma, which show a high degree of internuclear variability.3 Special techniques such as Ki-67 staining and immunohistochemistry studies for cytokeratin subtypes CK8, CK7, and CK 19 might guide in pathologically differentiating SNUC from nasopharyngeal carcinoma and squamous cell carcinoma.3,6 To assist in formulating a prognosis, Miyamoto et al developed a staging system based on the Hyams pathologic grading system and the Kadish staging system for esthesioneuroblastoma.7 Both systems independently predict outcomes.
ISSN:0145-5613
1942-7522
DOI:10.1177/014556130908801204