A chiron approach to the total synthesis of cytotoxic (+)-muricatacin and (+)-5- epi-muricatacin from d-ribose

A chiron approach strategy toward the total synthesis of (+)-muricatacin and (+)-5- epi-muricatacin starting from commercially available and inexpensive d-ribose through the key intermediate ( S)-5-(( R)-1-hydroxyallyl)furan-2(5 H)-one has been disclosed.

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Bibliographic Details
Published in:Carbohydrate research 2010-01, Vol.345 (1), p.41-44
Main Authors: Ghosal, Partha, Kumar, Vikas, Shaw, Arun K.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
d-Ribose
epi-Muricatacin
Furans - chemical synthesis
Furans - chemistry
Muricatacin
Ribose - chemistry
Stereoisomerism
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Summary:A chiron approach strategy toward the total synthesis of (+)-muricatacin and (+)-5- epi-muricatacin starting from commercially available and inexpensive d-ribose through the key intermediate ( S)-5-(( R)-1-hydroxyallyl)furan-2(5 H)-one has been disclosed.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2009.09.021