Congenital uterine anomalies affecting reproduction

The following review seeks to summarise the current data regarding reproductive outcomes associated with congenital uterine anomalies. Such malformations originate from adverse embryologic events ranging from agenesis to lateral and vertical fusion defects. Associated renal anomalies are common both...

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Bibliographic Details
Published in:Best practice & research. Clinical obstetrics & gynaecology 2010-04, Vol.24 (2), p.193-208
Main Authors: Reichman, David E., MD, Laufer, Marc R., MD
Format: Article
Language:English
Subjects:
Abortion, Habitual - etiology
arcuate
bicornuate
Congenital Abnormalities - classification
Congenital Abnormalities - diagnosis
Congenital Abnormalities - epidemiology
didelphys
Female
Humans
Incidence
Müllerian anomaly
Obstetrics and Gynecology
paramesonephric duct
Pregnancy
Pregnancy Outcome
septate
unicornuate
Uterus - abnormalities
Uterus - embryology
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Description
Summary:The following review seeks to summarise the current data regarding reproductive outcomes associated with congenital uterine anomalies. Such malformations originate from adverse embryologic events ranging from agenesis to lateral and vertical fusion defects. Associated renal anomalies are common both for the symmetric and asymmetric malformations. While fertility is minimally impacted upon by müllerian anomalies in most cases, such malformations have historically been associated with poor obstetric outcomes such as recurrent miscarriage, second trimester loss, preterm delivery, malpresentation and intrauterine foetal demise (IUFD). The following review delineates the existing literature regarding such outcomes and indicates therapies, where applicable, to optimise the care of such patients.
ISSN:1521-6934
1532-1932
DOI:10.1016/j.bpobgyn.2009.09.006