Impact of standardised review of intravenous antibiotic therapy 72 hours after prescription in two internal medicine wards

Summary Post-prescription review of hospital antibiotic therapy may contribute to more appropriate use. We estimated the impact of a standardised review of intravenous antibiotic therapy three days after prescription in two internal medicine wards of a university hospital. In one ward, we assessed t...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of hospital infection 2010-04, Vol.74 (4), p.326-331
Main Authors: Manuel, O, Burnand, B, Bady, P, Kammerlander, R, Vansantvoet, M, Francioli, P, Zanetti, G
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotic consumption
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial stewardship
Bacterial Infections - drug therapy
Biological and medical sciences
Drug Utilization Review - methods
Drug Utilization Review - standards
Female
Health Services Research
Hospitals
Humans
Infectious Disease
Infectious diseases
Infusions, Intravenous
Internal Medicine
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Quality of healthcare
Time Factors
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Post-prescription review of hospital antibiotic therapy may contribute to more appropriate use. We estimated the impact of a standardised review of intravenous antibiotic therapy three days after prescription in two internal medicine wards of a university hospital. In one ward, we assessed the charts of patients under intravenous antibiotic therapy using a standardised review process and provided feedback to the prescriber. There was no intervention in the other ward. After six months we crossed the allocation between the two wards. In all, 204 courses of antibiotic therapy were included in the intervention periods and 226 in the control periods. Post-prescription review led to proposals for modification in 46% of antibiotic courses. Time to treatment modification was 22% shorter in the intervention periods compared with the control periods (3.9 ± 5.2 days vs 5.0 ± 6.0 days, P = 0.007). Patients included in the intervention group had lower antibiotic consumption than patients in the control group, but the intervention had no significant impact on the overall antibiotic consumption of the two wards.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2009.07.011