Local anaesthetic toxicity

Abstract Background: Local anaesthesia has been used by British podiatrists since the early 1960s. The use of local anaesthesia has allowed for the advancement of scope of practice and the development of podiatric surgery. Local anaesthesia is however associated with potential risks and adverse reac...

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Bibliographic Details
Published in:Foot (Edinburgh, Scotland) Scotland), 2008-12, Vol.18 (4), p.192-197
Main Authors: Maher, Anthony J, Metcalfe, Stuart A, Parr, Steve
Format: Article
Language:English
Subjects:
Amides - adverse effects
Anesthetics, Local - adverse effects
Bupivacaine
Bupivacaine - adverse effects
Bupivacaine - analogs & derivatives
Cardiovascular Diseases - chemically induced
Central Nervous System Diseases - chemically induced
Humans
Intralipid
Local anaesthetics
Orthopedics
Podiatry
Toxicity
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Summary:Abstract Background: Local anaesthesia has been used by British podiatrists since the early 1960s. The use of local anaesthesia has allowed for the advancement of scope of practice and the development of podiatric surgery. Local anaesthesia is however associated with potential risks and adverse reactions including toxicity. Objectives: To review the current literature on the subject of local anaesthetic toxicity and to consider recent developments in the management of acute toxicity. Conclusions: Local anaesthesia although safe has the potential to cause serious harm in the event of toxicity. Appropriate steps should be taken to minimise the risk of toxicity and should it occur measures should be applied to minimise the consequences of toxicity. Such measures may include the use of Intralipid for resuscitation.
ISSN:0958-2592
1532-2963
DOI:10.1016/j.foot.2008.05.002