Fenofibrate reduces adiposity in pregnant and virgin rats but through different mechanisms

Fenofibrate has been proven to reduce adiposity. Since gestation produces an increase in white adipose tissue (WAT) mass, we comparatively studied this drug-effect in virgin and pregnant rats. Fenofibrate reduced lumbar WAT weight in both pregnant and virgin rats. Fenofibrate treatment did not modif...

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Bibliographic Details
Published in:BMB reports 2009-10, Vol.42 (10), p.679-684
Main Authors: Gonzalez, Maria del Carmen, Universidad CEU San Pablo, Madrid, Spain, Vidal, Hubert, University of Lyon, France, Herrera, Emilio, Universidad CEU San Pablo, Madrid, Spain, Bocos, Carlos, Universidad CEU San Pablo, Madrid, Spain
Format: Article
Language:English
Subjects:
Adipocytes - drug effects
Adipocytes - metabolism
ADIPOSE TISSUE
Adipose Tissue, White - cytology
Adipose Tissue, White - drug effects
Adiposity - drug effects
Animals
Biomarkers - metabolism
Fatty Acids - blood
Female
Fenofibrate
Fenofibrate - pharmacology
Gene Expression Regulation - drug effects
GESTACION
GESTATION
mRNA levels
Organ Size - drug effects
PREGNANCY
RAT
RATA
RATS
Rats, Sprague-Dawley
TEJIDO ADIPOSO
TISSU ADIPEUX
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Summary:Fenofibrate has been proven to reduce adiposity. Since gestation produces an increase in white adipose tissue (WAT) mass, we comparatively studied this drug-effect in virgin and pregnant rats. Fenofibrate reduced lumbar WAT weight in both pregnant and virgin rats. Fenofibrate treatment did not modify plasma free fatty acid (FFA) concentration in virgin rats, it greatly increased it in pregnant animals. Remarkable differences between the two groups were obtained for two proteins related to fatty acid oxidation and esterification and storing. Respectively, the mRNA levels of camitine palmitoyltransferase Ⅰ (CPT-Ⅰ) were increased by the fenofibrate only in the virgin rats and a similar finding was observed for the expression of phosphoenolpyruvate carboxykinase (PEPCK). These findings indicate that fenofibrate reduces adiposity in pregnant and virgin rats through different mechanisms: a) in virgin rats, by promoting fatty acid oxidation; and b) in pregnant rats, by enhancing fatty acid output.
ISSN:1976-6696
DOI:10.5483/BMBRep.2009.42.10.679