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Fenofibrate reduces adiposity in pregnant and virgin rats but through different mechanisms
Fenofibrate has been proven to reduce adiposity. Since gestation produces an increase in white adipose tissue (WAT) mass, we comparatively studied this drug-effect in virgin and pregnant rats. Fenofibrate reduced lumbar WAT weight in both pregnant and virgin rats. Fenofibrate treatment did not modif...
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| Published in: | BMB reports 2009-10, Vol.42 (10), p.679-684 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c377t-70887b6f1f96465ee0bb99443529435c23719d8676e7498d9b7a4f7cc2863d5b3 |
| container_end_page | 684 |
| container_issue | 10 |
| container_start_page | 679 |
| container_title | BMB reports |
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| creator | Gonzalez, Maria del Carmen, Universidad CEU San Pablo, Madrid, Spain Vidal, Hubert, University of Lyon, France Herrera, Emilio, Universidad CEU San Pablo, Madrid, Spain Bocos, Carlos, Universidad CEU San Pablo, Madrid, Spain |
| description | Fenofibrate has been proven to reduce adiposity. Since gestation produces an increase in white adipose tissue (WAT) mass, we comparatively studied this drug-effect in virgin and pregnant rats. Fenofibrate reduced lumbar WAT weight in both pregnant and virgin rats. Fenofibrate treatment did not modify plasma free fatty acid (FFA) concentration in virgin rats, it greatly increased it in pregnant animals. Remarkable differences between the two groups were obtained for two proteins related to fatty acid oxidation and esterification and storing. Respectively, the mRNA levels of camitine palmitoyltransferase Ⅰ (CPT-Ⅰ) were increased by the fenofibrate only in the virgin rats and a similar finding was observed for the expression of phosphoenolpyruvate carboxykinase (PEPCK). These findings indicate that fenofibrate reduces adiposity in pregnant and virgin rats through different mechanisms: a) in virgin rats, by promoting fatty acid oxidation; and b) in pregnant rats, by enhancing fatty acid output. |
| doi_str_mv | 10.5483/BMBRep.2009.42.10.679 |
| format | article |
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Since gestation produces an increase in white adipose tissue (WAT) mass, we comparatively studied this drug-effect in virgin and pregnant rats. Fenofibrate reduced lumbar WAT weight in both pregnant and virgin rats. Fenofibrate treatment did not modify plasma free fatty acid (FFA) concentration in virgin rats, it greatly increased it in pregnant animals. Remarkable differences between the two groups were obtained for two proteins related to fatty acid oxidation and esterification and storing. Respectively, the mRNA levels of camitine palmitoyltransferase Ⅰ (CPT-Ⅰ) were increased by the fenofibrate only in the virgin rats and a similar finding was observed for the expression of phosphoenolpyruvate carboxykinase (PEPCK). 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Since gestation produces an increase in white adipose tissue (WAT) mass, we comparatively studied this drug-effect in virgin and pregnant rats. Fenofibrate reduced lumbar WAT weight in both pregnant and virgin rats. Fenofibrate treatment did not modify plasma free fatty acid (FFA) concentration in virgin rats, it greatly increased it in pregnant animals. Remarkable differences between the two groups were obtained for two proteins related to fatty acid oxidation and esterification and storing. Respectively, the mRNA levels of camitine palmitoyltransferase Ⅰ (CPT-Ⅰ) were increased by the fenofibrate only in the virgin rats and a similar finding was observed for the expression of phosphoenolpyruvate carboxykinase (PEPCK). These findings indicate that fenofibrate reduces adiposity in pregnant and virgin rats through different mechanisms: a) in virgin rats, by promoting fatty acid oxidation; and b) in pregnant rats, by enhancing fatty acid output.</description><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>ADIPOSE TISSUE</subject><subject>Adipose Tissue, White - cytology</subject><subject>Adipose Tissue, White - drug effects</subject><subject>Adiposity - drug effects</subject><subject>Animals</subject><subject>Biomarkers - metabolism</subject><subject>Fatty Acids - blood</subject><subject>Female</subject><subject>Fenofibrate</subject><subject>Fenofibrate - pharmacology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>GESTACION</subject><subject>GESTATION</subject><subject>mRNA levels</subject><subject>Organ Size - drug effects</subject><subject>PREGNANCY</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>TEJIDO ADIPOSO</subject><subject>TISSU ADIPEUX</subject><issn>1976-6696</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNpFkE1LAzEQhnNQbK3-hEpunlrztcnmaMWqWBGKXryE7O6kjXQ_THaF_ntTWnAOM_DyzAw8CE0pmWci53eLt8UaujkjRM8Fm6dYKn2GxlQrOZNSyxG6jPGbEEmZYhdoRHWuhKJijL6W0LTOF8H2gANUQwkR28p3bfT9HvsGdwE2jW16bJsK__qwSVmiIy6GHvfb0A6bLa68cxAgUTWUW9v4WMcrdO7sLsL1aU7Q5_Lx4-F5tnp_enm4X81KrlQ_UyTPVSEddVoKmQGQotBaCJ4xnVrJuKK6yqWSoITOK10oK5wqS5ZLXmUFn6Db490utD8DxN7UPpaw29kG2iEaxXlOJKcykdmRLEMbYwBnuuBrG_aGEnMwaY4mzcGkEewQJ5Np7-b0YShqqP63ThoTMD0CzrbGboKP5nXNCCWpePr_BzZGe08</recordid><startdate>20091031</startdate><enddate>20091031</enddate><creator>Gonzalez, Maria del Carmen, Universidad CEU San Pablo, Madrid, Spain</creator><creator>Vidal, Hubert, University of Lyon, France</creator><creator>Herrera, Emilio, Universidad CEU San Pablo, Madrid, Spain</creator><creator>Bocos, Carlos, Universidad CEU San Pablo, Madrid, Spain</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091031</creationdate><title>Fenofibrate reduces adiposity in pregnant and virgin rats but through different mechanisms</title><author>Gonzalez, Maria del Carmen, Universidad CEU San Pablo, Madrid, Spain ; 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Since gestation produces an increase in white adipose tissue (WAT) mass, we comparatively studied this drug-effect in virgin and pregnant rats. Fenofibrate reduced lumbar WAT weight in both pregnant and virgin rats. Fenofibrate treatment did not modify plasma free fatty acid (FFA) concentration in virgin rats, it greatly increased it in pregnant animals. Remarkable differences between the two groups were obtained for two proteins related to fatty acid oxidation and esterification and storing. Respectively, the mRNA levels of camitine palmitoyltransferase Ⅰ (CPT-Ⅰ) were increased by the fenofibrate only in the virgin rats and a similar finding was observed for the expression of phosphoenolpyruvate carboxykinase (PEPCK). 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| identifier | ISSN: 1976-6696 |
| ispartof | BMB reports, 2009-10, Vol.42 (10), p.679-684 |
| issn | 1976-6696 |
| language | eng |
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| source | Free Full-Text Journals in Chemistry |
| subjects | Adipocytes - drug effects Adipocytes - metabolism ADIPOSE TISSUE Adipose Tissue, White - cytology Adipose Tissue, White - drug effects Adiposity - drug effects Animals Biomarkers - metabolism Fatty Acids - blood Female Fenofibrate Fenofibrate - pharmacology Gene Expression Regulation - drug effects GESTACION GESTATION mRNA levels Organ Size - drug effects PREGNANCY RAT RATA RATS Rats, Sprague-Dawley TEJIDO ADIPOSO TISSU ADIPEUX |
| title | Fenofibrate reduces adiposity in pregnant and virgin rats but through different mechanisms |
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