Endothelial nitric oxide synthase and nicotinamide adenosine dinucleotide phosphate oxidase p22phox gene (C242T) polymorphisms and systemic lupus erythematosus in a Chinese Population

Genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) and nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase p22phox are linked with the expression and/or progression of vascular disease. We hypothesized that these polymorphisms may influence the development and/or progres...

Full description

Saved in:
Bibliographic Details
Published in:Lupus 2010-02, Vol.19 (2), p.192-196
Main Authors: Tang, F-Y., Xie, X-W., Ling, G-H., Liu, F-Y.
Format: Article
Language:English
Subjects:
Adenosine
Alleles
Asian Continental Ancestry Group - genetics
Autoimmune diseases
Blood & organ donations
Cardiovascular disease
Case-Control Studies
China
Disease Progression
DNA polymerase
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic testing
Genotype & phenotype
Humans
Kidney diseases
Lupus
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - physiopathology
Mutation
NADPH Oxidases - genetics
Nephrology
Nitric oxide
Nitric Oxide Synthase Type III - genetics
Patients
Polymerase Chain Reaction
Polymorphism
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) and nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase p22phox are linked with the expression and/or progression of vascular disease. We hypothesized that these polymorphisms may influence the development and/or progression of systemic lupus erythematosus (SLE), given their linkage with vascular disease. DNA from patients with SLE (n = 90) and their age- and sex-matched controls (n = 86) from The Second Xiangya Hospital of Central South University was assessed for eNOS and NADPH oxidase p22phox polymorphisms. These polymorphisms were examined by restriction fragment length polymorphism—polymerase chain reaction. The allele frequency of the NADPH oxidase p22phox gene C242T polymorphisms significantly varied between the SLE patients and the controls. We found no association of the eNOS polymorphism with the development of renal disease. These results indicated that the etiology of patients with SLE is associated with NADPH oxidase p22phox gene C242T polymorphisms. There was no significant increased risk of SLE associated with eNOS polymorphisms in the Chinese population. Lupus (2010) 19, 192—196.
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203309348980