Long-term treatment of Langerhans cell histiocytosis of the mandibular condyle with indomethacin

Langerhans cell histiocytosis (LCH) most commonly occurs as a localized solitary bone lesion and appears predominantly in pediatric patients. LCH is characterized by the proliferation and accumulation of Langerhans cells which may cause pain and adjacent soft-tissue swelling. This disease is of clin...

Full description

Saved in:
Bibliographic Details
Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2010-04, Vol.109 (4), p.e13-e21
Main Authors: Park, Ji Woon, DDS, MSD, Chung, Jin Woo, DDS, PhD
Format: Article
Language:English
Subjects:
Abscess - diagnosis
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis, Infectious - diagnosis
Child
Dentistry
Diagnosis, Differential
Follow-Up Studies
Histiocytosis, Langerhans-Cell - diagnosis
Histiocytosis, Langerhans-Cell - drug therapy
Humans
Indomethacin - therapeutic use
Longitudinal Studies
Male
Mandibular Condyle - drug effects
Mandibular Condyle - pathology
Mandibular Diseases - diagnosis
Mandibular Diseases - drug therapy
Mandibular Neoplasms - diagnosis
Periarthritis - diagnosis
Phosphopyruvate Hydratase - analysis
Range of Motion, Articular - physiology
S100 Proteins - analysis
Surgery
Temporomandibular Joint Disorders - diagnosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Langerhans cell histiocytosis (LCH) most commonly occurs as a localized solitary bone lesion and appears predominantly in pediatric patients. LCH is characterized by the proliferation and accumulation of Langerhans cells which may cause pain and adjacent soft-tissue swelling. This disease is of clinical importance to dental professionals because LCH commonly involves the oral and maxillofacial region and early symptoms can be manifested in the jaw and, when overlooked, may result in extensive destruction of the involved structures. Considering the fact that this is a relatively rare entity, close investigation of the cases that are encountered are warranted. Herein we report a case of LCH occurring in the left condyle of an 11-year-old boy that initially showed clinical symptoms mimicking an abscess of the temporomandibular joint. The clinical and radiographic features, differential diagnosis, treatment, and long-term follow-up of this patient with indomethacin are presented.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2009.12.013