Outcomes of Domino Liver Transplantation: A Single Institution's Experience

• Published in: Transplantation proceedings 2010-03, Vol.42 (2), p.644-646
• Main Authors: Marín-Gómez, L.M, Gómez-Bravo, M.Á, Barrera-Pulido, L, Bernal-Bellido, C, Álamo-Martínez, J.M, Suárez-Artacho, G, Díez-Canedo, J.S, Sousa-Martín, J.M
• Format: Article
• Language: English
• Subjects: Adult; Amyloid Neuropathies, Familial - surgery; Biological and medical sciences; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Survival - physiology; Hepatectomy; Humans; Informed Consent; Liver Failure - surgery; Liver Transplantation - methods; Liver Transplantation - mortality; Liver Transplantation - physiology; Liver, biliary tract, pancreas, portal circulation, spleen; Male; Medical sciences; Middle Aged; Postoperative Complications - epidemiology; Retrospective Studies; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Survivors; Tissue Donors; Tissue, organ and graft immunology; Waiting Lists
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2010.02.012

Abstract Aims Domino liver transplantation (DLT) is a strategy to increase the donor pool. Explanted liver from patients with familial amyloidotic polyneuropathy (FAP) are often used as domino grafts, because the liver is normal apart from the production of the mutated transthyretin variant. We present the outcomes for both donors and recipients of DLT. Materials and Methods Retrospective analysis of initial DLT for 16 consecutive adult patients performed between July 2004 and July 2009. All cases of FAP donor to grafts were removed preserving the cava vein with reconstruction of the hepatic veins, except the first and seventh cases, where in we removed the retrohepatic vena cava with the liver without venovenous bypass. The postoperative follow-up period for surviving DLT recipients at the end of September 2009 was 2–62 months (mean, 26). Results Two patients out of 8 FAP donors died due to pulmonary thromboembolism on the 31st postransplant day, or sepsis at 35 days namely, an overall survival of 75%. One patient out of 8 recipients died namely, an early portal thrombosis on the 22nd postransplant day) with a crude survival of 87.5% in the recipient group ( P = no significant [NS]). Four grafts from 8 FAP donors were lost—2 deaths and 2 retransplants due to thrombotic events on the first and second postransplant day—with a crude survival of 50%. Two of 8 recipients lost their grafts: 1 death and 1 retransplantation for an acute Budd-Chiari syndrome on the first postransplant day with a crude survival of 75% in the recipient group ( P = not significant [NS]). Conclusion We believe that the FAP liver graft is an excellent option for selected patients. Special care must be taken with thrombotic events.