Composition, Cytotoxicity and Antioxidant Activity of the Essential Oil of Dracocephalum surmandinum from Iran

The composition of the hydrodistilled essential oil from the aerial parts of Dracocephalum surmandinum was analyzed by GC and GC-MS. Monoterpenoids, including oxygenated compounds and hydrocarbons, comprising 63.4 and 33.9%, respectively, were the principal compound groups of the essential oil. In t...

Full description

Saved in:
Bibliographic Details
Published in:Natural product communications 2010-02, Vol.5 (2), p.341-344
Main Authors: Sonboli, Ali, Esmaeili, Mohammad Ali, Gholipour, Abbas, Kanani, Mohammad Reza
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antioxidants - chemistry
Antioxidants - pharmacology
Biphenyl Compounds
Cell Line, Tumor
Humans
Inhibitory Concentration 50
Iran
Lamiaceae - chemistry
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
Picrates
Plant Oils - chemistry
Plant Oils - pharmacology
Rats
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The composition of the hydrodistilled essential oil from the aerial parts of Dracocephalum surmandinum was analyzed by GC and GC-MS. Monoterpenoids, including oxygenated compounds and hydrocarbons, comprising 63.4 and 33.9%, respectively, were the principal compound groups of the essential oil. In total, 25 constituents accounting for 97.8% of the oil were identified. Perilla aldehyde (54.3%) and limonene (30.1%) were characterized as the main components. The essential oil of D. surmandinum and its two main constituents showed a marked antioxidant and radical scavenging activity using different model systems, including 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and β-carotene-linoleic acid blenching assays. The results of cytotoxicity activity using the MTT assay exhibited that the oil of D. surmandinum has a good effect against human breast adenocarcinoma (MCF-7) and erythromyeloblastoid leukemia cell lines (K562) with IC50 values of 14 and 16 μg/mL, respectively. The cytotoxic potential of D. surmandinum oil against rat adrenal pheochromocytoma cell line (PC 12) was weak (IC50 of >100 μg/mL). Perilla aldehyde and limonene, the main constituents of D. surmandinum essential oil, inhibited all investigated cell growth in a dose- and time-dependent manner with IC50 values ranged from 0.25-5.0 mmol/L.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1000500234