Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer's disease

Recent neuroanatomical and functional neuroimaging studies indicate that the anterior part of the hippocampus, rather than the whole structure, may be specifically involved in episodic memory. In the present work, we examined whether anterior structural measurements are superior to other regional or...

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Bibliographic Details
Published in:Neuropsychologia 2010-04, Vol.48 (5), p.1447-1453
Main Authors: Yakushev, Igor, Müller, Matthias J., Lorscheider, Markus, Schermuly, Ingrid, Weibrich, Carsten, Dellani, Paulo R., Hammers, Alexander, Stoeter, Peter, Fellgiebel, Andreas
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Age of Onset
Aged
Alzheimer Disease - epidemiology
Alzheimer Disease - physiopathology
Atrophy - epidemiology
Atrophy - pathology
Atrophy - physiopathology
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diffusion-tensor imaging
Episodic memory
Female
Functional differentiation
Geriatrics
Hippocampus
Hippocampus - pathology
Hippocampus - physiopathology
Humans
Longitudinal axis
Magnetic Resonance Imaging
Male
Medical sciences
Memory Disorders - diagnosis
Memory Disorders - epidemiology
Memory Disorders - physiopathology
Mental Recall
Mild cognitive impairment
Neurology
Organic mental disorders. Neuropsychology
Predictive Value of Tests
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:Recent neuroanatomical and functional neuroimaging studies indicate that the anterior part of the hippocampus, rather than the whole structure, may be specifically involved in episodic memory. In the present work, we examined whether anterior structural measurements are superior to other regional or global measurements in mapping functionally relevant degenerative alterations of the hippocampus in Alzheimer's disease (AD). Twenty patients with early AD (MMSE 25.7±1.7) and 18 healthy controls were studied using magnetic resonance and diffusion-tensor imaging. Using a regions-of-interest analysis, we obtained volumetric and diffusivity measures of the hippocampal head and body-tail-section as well as of the whole hippocampus. Detailed cognitive evaluation was based on the CERAD battery. All volumetric measures as well as diffusivity of the hippocampus head were significantly (p
ISSN:0028-3932
1873-3514
DOI:10.1016/j.neuropsychologia.2010.01.014